منابع مشابه
Controlling Accessibility in Agile Projects with the Access Modifier Modifier
Access modifiers like public and private let the programmer control the accessibility of class members. Restricted accessibility supports encapsulation, i.e., the hiding of implementation details behind the interface of a class. However, what is an implementation detail and what makes the interface of a class is often subject to change: especially in an agile setting (with absence of an upfront...
متن کاملModeling covalent-modifier drugs.
In this review, we present a summary of how computer modeling has been used in the development of covalent-modifier drugs. Covalent-modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for a target with complementary reactivity and result in increased binding affinities due to the strength of the covalent bond formed. In...
متن کاملLengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins
Spider gating modifier toxins (GMTs) are potent modulators of voltage-gated ion channels and have thus attracted attention as drug leads for several pathophysiological conditions. GMTs contain three disulfide bonds organized in an inhibitory cystine knot, which putatively confers them with high stability; however, thus far, there has not been a focused study to establish the stability of GMTs i...
متن کاملThe Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
PURPOSE Epigenetic dysregulation is known to be an important contributor to myeloma pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic mutations in epigenetic modifiers has not been reported previously. We sought to address this using the results from whole-exome sequencing in the context of a large prospective clinical trial of newly diagnosed patients and targete...
متن کاملNatural Fiber Reinforced Poly(vinyl chloride) Composites: Effect of Fiber Type and Impact Modifier
Poly(vinyl chloride) (PVC) and natural fiber composites were prepared by melt compounding and compression molding. The influence of fiber type (i.e., bagasse, rice straw, rice husk, and pine fiber) and loading level of styrene-ethylene-butylene-styrene (SEBS) block copolymer on composite properties was investigated. Mechanical analysis showed that storage modulus and tensile strength increased ...
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ژورنال
عنوان ژورنال: Seikei-Kakou
سال: 2011
ISSN: 0915-4027,1883-7417
DOI: 10.4325/seikeikakou.23.486